Sairam Parthasarathy, MD

Director, Center for Sleep and Circadian Sciences, UA Health Sciences
Medical Director, Center for Sleep Disorders, Banner – University Medical Center Tucson
Interim Chief, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine
Professor, Medicine

Sleep intervention during Acute Lung Injury (R01 NIH/NHLBiHL095748):  The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury(ALI) and acute respiratory distress syndrome (ARDS). NCT01050699

Positive airway pressure therapy for sleep-disordered breathing (ADVENT-HF; Canadian Institute of Health Research [CIHR] and Toronto Rehabilitation Institute, Toronto, Canada):  The central purpose of this proposal is to assess the effect of adaptive servo ventilation (ASV) on mortality and cardiovascular hospitalizations in ptients with chronic heart failure and sleep apnea.

Adherence to CPAP Therapy in patients with sleep-disordered breathing (US Dept. of Veterans Affairs; PPO 10-066):  Our overall aim is to assess the feasibility and acceptability of a CPAP adherence program driven by trained "peer-buddies" with sleep apnea. NCT01164683

Sleep deprivation in murine models (Johrei foundation):  The central purpose of this proposal is to study the sleep-promoting effects of Johrei treatment in a murine sleep deprivation model.

Research Summary: 

Dr. Parthasarathy has expertise in non-invasive home ventilation for sleep-related breathing disorders and invasive ventilation in critically ill patients. His major areas of focus have been in promoting adherence to non-invasive ventilation devices, including continuous positive airway pressure (CPAP) devices, in the home setting and patient-ventilator interaction during critical illness. He serves as chief of the Division of Pulmonary, Allergy, Critical Care & Sleep Medicine at the University of Arizona College of Medicine – Tucson, founding director of the UArizona Center for Sleep & Circadian Sciences, medical director of the Center for Sleep Disorders at Banner – University Medical Center Tucson, and as a special advisor to the National Institutes of Health and National Heart, Lung, and Blood Institute.

Select Publications


Bailey, O., S. Parthasarathy, and D. Combs, "Too Little, but Still Great?", J Clin Sleep Med, vol. 14, issue 6, pp. 907-908, 2018 Jun 15. PMCID: PMC5991944  PubMed ID: 29852920 
Sawani, A., M. Farhangi, C. Aluganti N, T. M. Maul, S. Parthasarathy, J. Smallwood, and J. L. Wei, "Limiting Dietary Sugar Improves Pediatric Sinonasal Symptoms and Reduces Inflammation.", J Med Food, vol. 21, issue 6, pp. 527-534, 2018 Jun. PubMed ID: 29851540 
Parthasarathy, S., "The Reply.", Am J Med, vol. 131, issue 6, pp. e271, 2018 Jun. PubMed ID: 29784200 
Narasimhulu, C. Aluganti, A. Riad, and S. Parthasarathy, "Sesame Oil and an Aqueous Extract Derived from Sesame Oil Enhance Regression of Preexisting Atherosclerotic Lesions in Low-Density Lipoprotein Receptor Knockout Mice.", J Med Food, vol. 21, issue 7, pp. 641-646, 2018 Jul. PMCID: PMC6065523  PubMed ID: 29957121 
Parthasarathy, S., K. Henry, H. Pei, J. Clayton, M. Rempala, D. Johns, O. De Frutos, P. Garcia, C. Mateos, S. Pleite, et al., "Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.", Bioorg Med Chem Lett, vol. 28, issue 10, pp. 1887-1891, 2018 Jun 01. PubMed ID: 29655979