Sleep intervention during Acute Lung Injury (R01 NIH/NHLBiHL095748): The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury(ALI) and acute respiratory distress syndrome (ARDS). Clinicaltrials.gov# NCT01050699
Positive airway pressure therapy for sleep-disordered breathing (ADVENT-HF; Canadian Institute of Health Research [CIHR] and Toronto Rehabilitation Institute, Toronto, Canada): The central purpose of this proposal is to assess the effect of adaptive servo ventilation (ASV) on mortality and cardiovascular hospitalizations in ptients with chronic heart failure and sleep apnea. Clinicaltrials.gov#NCT01128816
Adherence to CPAP Therapy in patients with sleep-disordered breathing (US Dept. of Veterans Affairs; PPO 10-066): Our overall aim is to assess the feasibility and acceptability of a CPAP adherence program driven by trained "peer-buddies" with sleep apnea. Clinicaltrials.gov# NCT01164683
Sleep deprivation in murine models (Johrei foundation): The central purpose of this proposal is to study the sleep-promoting effects of Johrei treatment in a murine sleep deprivation model.
Dr. Parthasarathy has expertise in non-invasive home ventilation for sleep-related breathing disorders and invasive ventilation in critically ill patients. His major areas of focus have been in promoting adherence to non-invasive ventilation devices, including continuous positive airway pressure (CPAP) devices, in the home setting and patient-ventilator interaction during critical illness. He serves as chief of the Division of Pulmonary, Allergy, Critical Care & Sleep Medicine at the University of Arizona College of Medicine – Tucson, founding director of the UArizona Center for Sleep & Circadian Sciences, medical director of the Center for Sleep Disorders at Banner – University Medical Center Tucson, and as a special advisor to the National Institutes of Health and National Heart, Lung, and Blood Institute.